Cal. Code Regs. tit. 22 § 69403.12

Current through Register 2024 Notice Reg. No. 49, December 6, 2024
Section 69403.12 - Neurotoxicity
(a) The neurotoxicity hazard trait is defined as the occurrence of adverse effects, following exposure to a chemical substance, on the structure or function of the central or peripheral nervous system, such as neurochemical, neurophysiological, or behavioral effects.
(b) Toxicological endpoints for neurotoxicity include, but are not limited to those indicating: pathological changes in the central or peripheral nervous systems; abnormal electrical activity of the central or peripheral nervous systems; altered neurochemical synthesis, storage, secretion or uptake; impairments in neuromuscular control; mood disorders; behavioral changes; impaired cognition including IQ decrements.
(c) Other relevant neurotoxicity data include but are not limited to: invitro indicators of neurotoxicity in isolated nervous system cells; structural or mechanistic similarity to other chemical substances that are neurotoxic.

Cal. Code Regs. Tit. 22, § 69403.12

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).

Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.

1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).