Section 69403.11 - Neurodevelopmental Toxicity(a) The neurodevelopmental toxicity hazard trait is defined as the occurrence of adverse effects on development of the nervous system resulting from exposure to a chemical substance during the developmental period, including effects on the structure or function of the central or peripheral nervous system, such as neurochemical, neurophysiological, neuroanatomical, or behavioral alterations.(b) Toxicological endpoints for neurodevelopmental toxicity include but are not limited to: alterations in neuromuscular, sensory, cognitive (learning and memory), integrative or autonomic functions; neuropathological changes including gross change in size or shape of the brain or brain regions, death of neuronal precursors, abnormal proliferation, migration, differentiation, or alterations in transient developmental structures, or hydrocephalus.(c) Other relevant developmental neurotoxicity data include but are not limited to evidence of neurotoxicity in adult animals; in vitro indicators of toxicity such as in isolated neuronal precursor cells or stem cells, or neurosphere models; structural or mechanistic similarity to chemicals that are toxic to the developing nervous system.Cal. Code Regs. Tit. 22, § 69403.11
1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51). Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.
1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).