For a new microorganism to qualify for either exemption under this subpart, introduced genetic material must meet all of the criteria listed in this section.
Sequence Source | Toxin Name |
Corynebacterium diphtheriae & C. ulcerans | Diphtheria toxin |
Pseudomonas aeruginosa | Exotoxin A |
Shigella dysenteriae | Shigella toxin (Shiga toxin, Shigella dysenteriae type I toxin, Vero cell toxin) |
Abrus precatorius, seeds | Abrin |
Ricinus communis, seeds | Ricin |
Sequence Source | Toxin Name |
Clostridium botulinum | Neurotoxins A, B, C1, D, E, F, G (Botulinum toxins, botulinal toxins) |
Clostridium tetani | Tetanus toxin (tetanospasmin) |
Proteus mirabilis | Neurotoxin |
Staphylococcus aureus | Alpha toxin (alpha lysin) |
Yersinia pestis | Murine toxin |
Snake toxins | |
Bungarus caeruleus | Caeruleotoxin |
Bungarus multicinctus | Beta-bungarotoxin (phospholipase) |
Crotalus spp. | Crotoxin (phospholipase) |
Dendroaspis viridis | Neurotoxin |
Naja naja varieties | Neurotoxin |
Notechia scutatus | Notexin (phospholipase) |
Oxyuranus scutellatus | Taipoxin |
Invertebrate toxins | |
Chironex fleckeri | Neurotoxin |
Androctnus australis | Neurotoxin |
Centruroides sculpturatus | Neurotoxin |
Sequence Source | Toxin Name |
Bacillus alve | Alveolysin |
Bacillus cereus | Cereolysin |
Bacillus laterosporus | Laterosporolysin |
Bacillus thuringiensis | Thuringiolysin |
Clostridium bifermentans | Lysin |
Clostridium botulinum | Lysin |
Clostridium caproicum | Lysin |
Clostridium chauvoei | Delta-toxin |
Clostridium histolyticum | Epsilon-toxin |
Clostridium novyi | Gamma-toxin |
Clostridium oedematiens | Delta-toxin |
Clostridium perfringens | Theta-toxin (Perfringolysin) |
Clostridium septicum | Delta-toxin |
Clostridium sordellii | Lysin |
Clostridium tetani | Tetanolysin |
Listeria monocytogenes | Listeriolysin (A B) |
Streptococcus pneumoniae | Pneumolysin |
Streptococcus pyogene | Streptolysin O (SLO) |
Sequence Source | Toxin Name |
Bacillus anthracis | Edema factor (Factors I II); Lethal factor (Factors II III) |
Bacillus cereus | Enterotoxin (diarrheagenic toxin, mouse lethal factor) |
Bordetella pertussis | Adenylate cyclase (Heat-labile factor); Pertussigen (pertussis toxin, islet activating factor, histamine sensitizing factor, lymphocytosis promoting factor) |
Clostridium botulinum | C2 toxin |
Clostridium difficile | Enterotoxin (toxin A) |
Clostridium perfringens | Beta-toxin; Delta-toxin |
Escherichia coli & other Enterobacteriaceae spp. | Heat-labile enterotoxins (LT); Heat-stable enterotoxins (STa, ST1 subtypes ST1a ST1b; also STb, STII) |
Legionella pneumophila | Cytolysin |
Vibrio cholerae & Vibrio mimicus | Cholera toxin (choleragen) |
Sequence Source | Toxin Name |
Clostridium bifermentans & other Clostridium spp | Lecithinase |
Clostridium perfringens | Alpha-toxin (phospholipase C, lecithinase); Enterotoxin |
Corynebacterium pyogenes & other Corynebacterium spp. | Cytolysin (phospholipase C), Ovis toxin (sphingomyelinase D) |
Staphylococcus aureus | Beta-lysin (beta toxin) |
Sequence Source | Toxin Name |
Adenia digitata | Modeccin |
Aeromonas hydrophila | Aerolysin (beta-lysin, cytotoxic lysin) |
Clostridium difficile | Cytotoxin (toxin B) |
Clostridium perfringens | Beta-toxin; Epsilon-toxin; Kappa-toxin |
Escherichia coli & other Enterobacteriaceae spp. | Cytotoxin (Shiga-like toxin, Vero cell toxin) |
Pseudomonas aeruginosa | Proteases |
Staphylococcus aureus | Gamma lysin (Gamma toxin); Enterotoxins (SEA, SEB, SEC, SED SEE); Pyrogenic exotoxins A B; Toxic shock syndrome toxins (TSST-1) |
Staphylococcus aureus & Pseudomonas aeruginosa | Leucocidin (leukocidin, cytotoxin) |
Streptococcus pyogenes | Streptolysin S (SLS); Erythrogenic toxins (scarlet fever toxins, pyrogenic exotoxins) |
Yersinia enterocolitica | Heat-stable enterotoxins (ST) |
40 C.F.R. §725.421