Table 1 to Paragraph (a)(1)-Urine, Initial Test Cutoff Levels for Drugs and Drug Metabolites
Drugs or drug metabolites | Cutoff level [nanograms (ng)/mL] |
Marijuana metabolites | 50 |
Cocaine metabolites | 150 |
Opioids: | |
Codeine/Morphine1 | 2,000 |
Hydrocodone/Hydromorphone | 300 |
Oxycodone/Oxymorphone | 100 |
6-acetylmorphine (6-AM) | 10 |
Phencyclidine (PCP) | 25 |
Amphetamines:2 | |
AMP/MAMP3 | 500 |
MDMA4/MDA5 | 500 |
1 Morphine is the target analyte for codeine/morphine testing.
2 Either a single initial test kit or multiple initial test kits may be used provided the single test kit detects each target analyte independently at the specified cutoff.
3 Methamphetamine (MAMP) is the target analyte for amphetamine (AMP)/MAMP testing.
4 Methylenedioxymethamphetamine.
5 Methylenedioxyamphetamine.
Table 2 to Paragraph (a)(1)-Oral Fluid, Initial Test Cutoff Levels for Drugs and Drug Metabolites
Drugs or drug metabolites | Cutoff level1 [nanograms (ng)/mL] |
Marijuana (THC)23 | 4 |
Cocaine/Benzoylecgonine | 15 |
Opioids: | |
Codeine/Morphine | 30 |
Hydrocodone/Hydromorphone | 30 |
Oxycodone/Oxymorphone | 30 |
6-acetylmorphine (6-AM) | 43 |
Phencyclidine (PCP) | 10 |
Amphetamines: | |
AMP/MAMP4 | 50 |
MDMA/MDA5 | 50 |
1 For grouped analytes (i.e., two or more analytes in the same drug class with the same initial test cutoff):
Immunoassay: The test must be calibrated with one analyte from the group identified as the target analyte. The cross reactivity of the immunoassay to the other analyte(s) within the group must be 80 percent or greater; if not, separate immunoassays must be used for the analytes within the group. Alternative technology: Either one analyte or all analytes from the group must be used for calibration, depending on the technology. At least one analyte within the group must have a concentration equal to or greater than the initial test cutoff or, alternatively, the sum of the analytes present.2 An immunoassay must be calibrated with the target analyte, delta-9-tetrahydrocannabinol (THC).
3 Alternate technology (THC and 6-AM): The confirmatory tests cutoff must be used for an alternate technology initial test that is specific for the target analyte (i.e., 2 ng/mL for THC, 2 ng/mL for 6-AM).
4 Amphetamine (AMP) and methamphetamine (MAMP).
5 Methylenedioxymethamphetamine (MDMA) and methylenedioxyamphetamine (MDA).
Table 3 to Paragraph (b)(1)-Urine, Confirmatory Test Cutoff Levels for Drugs and Drug Metabolites
Drugs or drug metabolites | Cutoff level (ng/mL) |
Marijuana metabolite1 | 15 |
Cocaine metabolite2 | 100 |
Opioids: | |
Morphine | 2,000 |
Codeine | 2,000 |
Hydrocodone | 100 |
Hydromorphone | 100 |
Oxycodone | 100 |
Oxymorphone | 100 |
6-acetylmorphine (6-AM) | 10 |
Phencyclidine (PCP) | 25 |
Amphetamines: | |
Amphetamine | 250 |
Methamphetamine3 | 250 |
Methylenedioxymethamphetamine (MDMA) | 250 |
Methylenedioxyamphetamine (MDA) | 250 |
1 As delta-9-tetrahydrocannabinol-9-carboxylic acid (THCA).
2 As benzoylecgonine.
3 To be reported positive for methamphetamine, a specimen must also contain amphetamine at a concentration equal to or greater than 100 ng/mL.
Table 4 to Paragraph (b)(1)-Oral Fluid, Confirmatory Test Cutoff Levels for Drugs and Drug Metabolites
Drugs or drug metabolites | Cutoff level [nanograms (ng)/mL] |
Marijuana (THC) | 2 |
Cocaine | 8 |
Benzoylecgonine | 8 |
Opioids: | |
Codeine | 15 |
Morphine | 15 |
Hydrocodone | 15 |
Hydromorphone | 15 |
Oxycodone | 15 |
Oxymorphone | 15 |
6-acetylmorphine (6-AM) | 2 |
Phencyclidine (PCP) | 10 |
Amphetamines: | |
Amphetamine | 25 |
Methamphetamine | 25 |
Methylenedioxymethamphetamine (MDMA) | 25 |
Methylenedioxyamphetamine (MDA) | 25 |
10 C.F.R. §26.163