Section 69403.16 - Respiratory Toxicity(a) The respiratory toxicity hazard trait is defined as the occurrence of adverse effects on the structure or function of the respiratory tract following exposure to a chemical substance, including respiratory tract injury or decreased ability of the lungs to function in gas exchange.(b) Toxicological endpoints for respiratory toxicity include, but are not limited to those indicating: respiratory irritation; pathological changes to the airway or other lung structures; inflammation; fibrosis; hypersensitivity pneumonitis; airways hyperresponsiveness; altered lung function; asthma; airways remodeling; increased respiratory infections; altered composition of bronchoalveolar lavage fluid.(c) Other relevant data include but are not limited to: in vitro evidence for respiratory toxicity; particle size distribution inclusive of respirable particles; respirable fibers; long half-life in the lung; chemical reactivity; redox potential; structural or mechanistic similarity to other chemical substances that are toxic to the respiratory system.Cal. Code Regs. Tit. 22, § 69403.16
1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51). Note: Authority cited: Sections 25256.1 and 59012, Health and Safety Code. Reference: Sections 25256.1 and 59012, Health and Safety Code.
1. New section filed 12-20-2011; operative 1-29-2012 (Register 2011, No. 51).