Ex Parte Martin et alDownload PDFPatent Trial and Appeal BoardMar 11, 201914217534 (P.T.A.B. Mar. 11, 2019) Copy Citation UNITED STA TES p A TENT AND TRADEMARK OFFICE APPLICATION NO. FILING DATE FIRST NAMED INVENTOR 14/217,534 03/18/2014 Timothy M. Martin 111801 7590 03/13/2019 FMC I Fox Rothschild LLP 2929 Walnut Street Philadelphia, PA 19104 UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O. Box 1450 Alexandria, Virginia 22313-1450 www .uspto.gov ATTORNEY DOCKET NO. CONFIRMATION NO. 115111.00041 (60966) 1085 EXAMINER VANHORN, ABIGAIL LOUISE ART UNIT PAPER NUMBER 1616 NOTIFICATION DATE DELIVERY MODE 03/13/2019 ELECTRONIC Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the following e-mail address(es): ipdocket@foxrothschild.com Andrea.Small@fmc.com patents@fmc.com PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte TIMOTHY M. MARTIN, WILLIAM SCHERZINGER, and MARGARITA GIA VIS 1,2 Appeal2018-002330 Application 14/217 ,534 Technology Center 1600 Before RICHARD M. LEBOVITZ, JEFFREY N. FRED MAN, and JOHN G. NEW, Administrative Patent Judges. NEW, Administrative Patent Judge. DECISION ON APPEAL 1 Appellants state that the real party-in-interest is FMC Corporation. App. Br. 2. 2 We note that Appellants' Brief lacks page numbers. We therefore number and refer to the pages seriatim, with the beginning page of the Appeal Brief as page 1. Appeal2018-002330 Application 14/217,534 SUMMARY Appellants file this appeal under 35 U.S.C. § I34(a) from the Examiner's Final Rejection of claims 1-2, 5-18, and 21-22 as unpatentable under 35 U.S.C. § I03(a) over the combination of Martin (US 2008/0206361 Al, August 28, 2008) ("Martin"), Shirley et al. (US 2008/0306026 Al, December 11, 2008) ("Shirley"), Brahm et al. (US 2012/0009238 Al, January 12, 2012) ("Brahm"), and Tsuda et al (US 2012/0156303 Al, June 21, 2012) ("Tsuda"). We have jurisdiction under 35 U.S.C. § 6(b). We AFFIRM. NATURE OF THE CLAIMED INVENTION Appellants' invention is directed to insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizer. Spec. Abstr. REPRESENTATIVE CLAIM Claim 1 is representative of the claims on appeal and recites: 1. A homogeneous insecticidal liquid composition compnsmg: a) unencapsulated bifenthrin; b) at least one encapsulated crop protection agent having a melting point of 50°C or less prepared via an interfacial polymerization carried out in the presence of the ingredients consisting essentially of the crop protection agent, a salt ofligninsulfonic acid, water, and inert organic solvent, polyfunctional polyisocyanate and a polyfunctional amine; 2 Appeal2018-002330 Application 14/217,534 c) a hydrated aluminum-magnesium silicate; and d) at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpolyglycoside, a naphthalenesulfonic acid formaldehyde condensate and a phosphate ester; and e) water. App. Br. 13. ISSUES AND ANALYSES We are persuaded by, and expressly adopt, the Examiner's findings, reasoning, and conclusions establishing that Appellants' claims are prima facie obvious over the cited prior art. We address the arguments raised by Appellants below. Issue 1 Appellants argue that the Examiner erred because the combined cited prior art fails to teach or suggest: [ A ]t least one encapsulated crop protection agent having a melting point of 50°C or less prepared via an interfacial polymerization carried out in the presence of the ingredients consisting essentially of the crop protection agent, a salt of ligninsulfonic acid, water, and inert organic solvent, polyfunctional polyisocyanate and a polyfunctional amine. App. Br. 6. Appellants further argue that there is no teaching or suggestion in the cited prior art references that would lead a person of ordinary skill in the art to combine their teachings to arrive at Appellants claimed composition. App. Br. 7. 3 Appeal2018-002330 Application 14/217,534 Analysis The Examiner finds that Martin teaches generally that formulations of insecticides combined with fertilizers are desirable in agricultural and related endeavors due to the multiple benefits conveyed by just one application in a single piece of equipment. Final Act. 5 ( citing Martin ,r 3). The Examiner finds that Martin is directed to such compositions, in which the insecticide comprises a pyrethoid, preferably bifenthrin, a hydrated aluminum- magnesium silicate and at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpolyglycoside, a naphthalene-sulfonic acid formaldehyde condensate and a phosphate ester. Id. at 6 (citing Martin ,r 5, 7). The Examiner finds that Martin teaches that the phosphate esters included in the composition may be nonyl phenol phosphate ester and a tridecyl alcohol ethoxylated phosphate potassium salt. Final Act. 6 ( citing Martin ,r 9). The Examiner finds that Martin further teaches that the composition may also comprise at least one of an anti-freeze agent, an anti- foam agent and a biocide, and may further comprise an insecticidally- effective amount of one or more additional insecticides. Id. (citing Martin ,r,r 9, 10). The Examiner finds that Martin additionally teaches the inclusion of a liquid fertilizer. Id. ( citing Martin ,r 11, claims 10, 13 ). However, the Examiner finds that, although Martin suggests the composition can comprise additional actives such as insecticides, Martin does not expressly teach the incorporation of an encapsulated crop protection agent. Final Act. 7. 4 Appeal2018-002330 Application 14/217,534 The Examiner finds that Shirley teaches the formulation of capsules prepared with at least one other pesticide which broadens the spectrum of pest control of a first pesticide. Final Act. 7 ( citing Shirley ,r 60). The Examiner finds that Brahm is directed to a method for treating crops with an encapsulated pesticide. Final Act. 7. Specifically, the Examiner finds Brahm teaches a composition comprising an encapsulated pesticide, in which the encapsulation material comprises a polyfunctional isocyanate and a diamine (i.e., a polyfunctional amine) and in the core of the capsules of the encapsulated pesticide at least 80% of the pesticide is dissolved in an organic solvent. Id. (citing Brahm claim 22). The Examiner finds Brahm teaches that suitable wall forming materials include polyfunctional isocyanate and polyfunctional amine. Id. (citing Brahm ,r,r 136, 138). The Examiner finds Brahm further teaches mixtures of encapsulated pesticide and a non-encapsulated additional pesticide, which may be present in a suspended, emulsified, but preferably dissolved form. Id. at 7-8 ( citing Brahm ,r 102). The Examiner finds Tsuda teaches a method of microcapsule production. Final Act. 8. Specifically, the Examiner finds that Tsuda teaches that the pesticide is suspended in a mixture of an organic solvent and a polyisocyanate. Id. The Examiner finds Tsuda teaches that the resultant suspension is mixed with water to give oil liquid droplets emulsified in water: an anionic surfactant is then added to the emulsion and the polyisocyanate reacts with a polyamine to form a coating film of a resin around the liquid droplet. Id. The Examiner finds Tsuda teaches that the anionic surfactant is a salt of ligninsulfonic acid. Id. (citing Tsuda ,r,r 0029- 0033). 5 Appeal2018-002330 Application 14/217,534 The Examiner concludes that it would have been obvious to a person of ordinary skill in the art to combine the teachings of Martin, Brahm, Tsuda, and Shirley utilize to include a microencapsulated pesticide in the composition of Martin. Final Act. 8. The Examiner concludes that a skilled artisan would have been motivated to utilize a microencapsulated pesticide with a non-encapsulated pesticide to broaden the spectrum of pest control, as taught by Shirley. Id. The Examiner further concludes that a person of ordinary skill in the art would have had a reasonable expectation of success, because Brahm teaches the use of both encapsulated and non-encapsulated pesticides. Id. Appellants acknowledge that Martin teaches a mixture of liquid fertilizer with bifenthrin, which is a stable mixture. App. Br. 7. Appellants assert that their claimed invention is a more complex mixture of non- encapsulated bifenthrin and an encapsulated crop protection agent that is also stable and ready to mix with a liquid fertilizer. Id. Appellants contend that the addition of an encapsulated crop protection agent is neither taught nor suggested by Martin. Id. Appellants argue that the Examiner incorrectly dismisses the complexity and inventive nature of the Appellants' claimed composition because formulations of encapsulated biologically active materials are known in the art. Id. However, Appellants argue, the claimed formulation of encapsulated and non-encapsulated active materials is not known. Id. Appellants argue further that none of the references singly teaches each element of the claimed invention, and none of the secondary references suggest combining their teachings with those of Martin. App. Br. 7. According to Appellants, this is instructive, because each of the secondary 6 Appeal2018-002330 Application 14/217,534 references was published after Martin yet none of them took the obvious step of teaching the composition claimed by Appellants. Id. Appellants contend that, although the Examiner may combine the references, the suggestion to combine the references should be clear from the references themselves. Id. Appellants argue that Martin does not suggest the incorporation of an encapsulated crop protection agent, and the other cited references teach encapsulated agents, but do not suggest the combination with the teachings of Martin, or that such a combination would form a stable homogenous mixture. Id. Nor, Appellants assert, do the references suggest the encapsulation of a crop protection prepared via an interfacial polymerization carried out in the presence of the ingredients consisting essentially of the crop protection agent, a salt of ligninsulfonic acid, water, and inert organic solvent, polyfunctional polyisocyanate and a polyfunctional amine. Id. Appellants further assert that chemical arts are unpredictable and the stability of complex mixtures occupies an unpredictable space within an unpredictable art. App. Br. 8. Appellants point to Drug Development Servc's, Physical Stability of Disperse Systems, 1 PARTICLE SCIENCES, TECH. BRIEF 1-2 (2009) ("Drug Dev."), which states that: "[S]uspension stability ... is somewhat of a moving target that each formulator must define on a case-by-case basis because it depends upon the timescale of the observations - how long do you need the system to remain 'stable"'? Id. ( quoting Drug Dev. 1 ). Appellants contend that it therefore stands to reason that any reasonable expectation of success based on Martin should be limited to a case-by-case basis, according to the teaching in Martin and as suggested by experts. Id. 7 Appeal2018-002330 Application 14/217,534 We are not persuaded by Appellants arguments. However, before addressing Appellants' patentability arguments on the merits, we must, as a matter of claim construction, consider Appellants' contention that the Examiner has misconstrued Appellants' claims with respect to the use of the transitional claim language "consisting essentially of." App. Br. 3. Appellants accuse the Examiner of holding Appellants to an unreasonable burden of persuasion by denying Appellants the use of "consisting essentially of' language, or otherwise ignoring the effect of such use. Id. at 4. Specifically, Appellants point to the Examiner's finding that stated that: "if the prior art teaches an encapsulated crop protection agent, it would appear to suggest the same claimed component instantly claimed." App. Br. 4. Appellants point to the Examiner's reliance upon PPG Industries Inc. v. Guardian Industries Corp., 156 F.3d 1351 (Fed. Cir. 1998) as holding that Appellants have the burden of showing that introduction of additional steps or components would materially change the characteristics of the invention, when the presumption that such is the case has been challenged. Id. Appellants then point to the Declaration of Timothy M. Martin, August 5, 2015 (the "Martin Declaration")3, and Drug Dev., as providing evidence that changing certain features would materially affect the homogeneity and the stability of the claimed composition. Id. Appellants argue that this evidence meets their burden of showing that a person of ordinary skill would have understood that obtaining or preserving a stable homogenous system would 3 Timothy M. Martin is one of the named inventors of the application on appeal. 8 Appeal2018-002330 Application 14/217,534 be subject to a number of physical and chemical interactions and actors. Id. at 4--5. Appellants argue further that, throughout their Specification, they stress that the invention is a composition that is, in one regard, a stable and homogenous mixture of bifenthrin with an encapsulated crop protection agent. App. Br. 5. Similarly, Appellants contend that, in another aspect, the present invention is a homogenous mixture of the bifenthrin, crop protection agent, and liquid fertilizer. Id. Appellants contend that the homogeneity and stability of these mixtures are basic and novel to the claimed invention and would be understood as such by one of ordinary skill in the art of formulation science or formulation chemistry. Id. We are not persuaded by Appellants that the Examiner has misconstrued the language of the claims. Appellants' complaint centers upon the use of the transitional term "consisting essentially of' in the limitation of claim 1 reciting: [ A ]t least one encapsulated crop protection agent having a melting point of 50°C or less prepared via an interfacial polymerization carried out in the presence of the ingredients consisting essentially of the crop protection agent, a salt of ligninsulfonic acid, water, and inert organic solvent, polyfunctional polyisocyanate and a polyfunctional amine; (Emphasis added). We construe this language to mean that the claimed encapsulated crop protection agent (i.e., a pesticide) consists essentially of: (1) the crop protection agent; (2) a salt of ligninsulfonic acid; (3) water; (4) an[] inert organic solvent, (5) polyfunctional polyisocyanate; and (6) a polyfunctional amine. Furthermore, we construe the overall claim to mean, 9 Appeal2018-002330 Application 14/217,534 from the language on its face, that the transitional term "consists essentially of' applies only to this limitation. By using the term "consisting essentially of," the drafter signals that the invention necessarily includes the listed ingredients and is open to unlisted ingredients that do not materially affect the basic and novel properties of the invention. A "consisting essentially of' claim occupies a middle ground between closed claims that are written in a "consisting of' format and fully open claims that are drafted in a "comprising" format. PPG, 156 F.3d at 1354. Consequently, the claimed encapsulated "crop protection agent" must contain the recited constituents, but may also contain other constituents, provided these additional constituents do not materially affect the basic and novel properties of the encapsulated crop protection agent. Tsuda is directed to a microcapsule containing a pesticidal compound of high water solubility and methods of production thereof. Tsuda ,r,r 1-2. Specifically, Tsuda teaches: A method of microcapsule production, wherein (1) at least one solid pesticidal compound whose water solubility at 20° C. is more than 100 ppm and at least one solid pesticidal compound whose water solubility at 20° C. is less than 30 ppm are suspended in a mixture of a compound of formula (I) defined in [1] 4 and a polyisocyanate, (2) the resultant suspension is mixed 4 Formula (1), as defined in [1] consists of: "A microcapsule in which a liquid droplet is coated with a resin, wherein in the droplet, a pesticidally active solid ingredient is suspended in a compound of formula (I): 10 Appeal2018-002330 Application 14/217,534 with water to give oil liquid droplets emulsified in water, (3) an anionic surfactant is added to the emulsion containing the liquid droplet, and then, the polyisocyanate in the liquid droplet is reacted with a polyol or a polyamine to form a coating film of a resin around the liquid droplet. ... wherein the anionic swfactant is a salt of ligninsulfonic acid. Tsuda ,r,r 29--33 ( emphases added and paragraph numbers omitted). Tsuda also teaches that: "Coating of the liquid droplet with a resin is usually carried out by forming a coating film of a resin by an interfacial polymerization method." Tsuda ,r 57. Tsuda thus teaches an encapsulated crop protection agent comprising: (1) the crop protection agent; (2) a salt of ligninsulfonic acid; (3) water; (4) an[] inert organic solvent; (5) polyfunctional polyisocyanate; and (5) a polyfunctional amine, as recited in claim 1. Tsuda thus teaches the elements of which this limitation "consists essentially of." Appellants point to no other constituents of the encapsulated crop protection agent recited in Tsuda that might otherwise materially affect the basic and novel properties of the claimed encapsulated crop protection agent. Rather, Appellants appear to argue that the overall stability and homogeneity of the claimed mixture of unencapsulated bifenthrin, encapsulated crop protection agent, and fertilizer are the basic and novel properties of the claimed invention. However, the "consisting essentially of' limitation applies only to the constituents of the 1.....----.... l,~~.u i ,:cu,,;;, (I) wherein R represents a Cl-C5 alkyl group." Tsuda ,r 5. 11 Appeal2018-002330 Application 14/217,534 encapsulated crop protection agent, and not to the overall claimed mixture. Furthermore, Appellants adduce no evidence of record to show that the encapsulated crop protection agent ( which corresponds to Appellants' claimed encapsulated agent) would destabilize or otherwise cause the claimed mixture to not be homogeneous. We therefore conclude that the Examiner properly relied upon Tsuda as teaching this disputed limitation. With respect to Appellants' arguments concerning the Examiner's conclusion that the claims on appeal are obvious over the cited prior art, we are similarly not persuaded. Appellants argue that that the addition of an encapsulated crop protection agent is neither taught nor suggested by Martin, and that: "the claimed formulation of encapsulated and non-encapsulated active materials is not known." See App. Br. 7. However, the Examiner points to Brahm, which expressly teaches that: In a preferred embodiment, the method according to the invention comprises the treatment with a mixture of an encapsulated pesticide and a non-encapsulated, additional pesticide. The additional pesticide may be selected from the aforementioned pesticides. The non-encapsulated, additional pesticide may be present in a dissolved, suspended and/or emulsified form. Preferably, the non-encapsulated, additional pesticide is present in a dissolved form. Brahm ,r 102 ( emphasis added). Brahm further teaches that: "A suitable insecticide may be a pyrethoid or a nicotinic receptor agonists/antagonists compound, more preferably a pyrethoid, especially alpha-cypermethrin." Id. Both bifenthrin and alpha-cypermethrinare are pyrethoid pesticides. See Spec. ,r 37. Appellants also argue that the references neither teach nor suggest the encapsulation of a crop protection prepared via an interfacial polymerization 12 Appeal2018-002330 Application 14/217,534 carried out in the presence of the ingredients consisting essentially of the crop protection agent, a salt of ligninsulfonic acid, water, and inert organic solvent, polyfunctional polyisocyanate and a polyfunctional amine. However, as we have demonstrated supra, Tsuda teaches this method, and these ingredients, explicitly. See Tsuda ,r,r 5, 29--33, 57. Appellants also argue that, due to the unpredictability of the chemical arts, "any reasonable expectation of success based on Martin should be limited to a case-by-case basis, according to the teaching in Martin and as suggested by experts." See App. Br. 8. However, Brahm, as quoted supra, expressly teaches the combination of encapsulated pesticides with non- encapsulated pyrethoid (bifenthrin) pesticides. Brahm ,r 102. The Martin Declaration is adduced by Appellants as demonstrating the unpredictability of the art. See App. Br. 4, Martin Deel. ,r 4. The Martin Declaration is primarily concerned with demonstrating that: "the essential components of [Dexter et al. (US 2010/0234225 Al, September 16, 2010) ("Dexter")] (for example MgS04 and xanthan gum) resulted in an unstable or heterogeneous system when mixing bifenthrin and encapsulated zeta cypermethrin with a liquid fertilizer." Martin Deel. ,r 4. The Martin Declaration concludes that: "The presence of the essential components of Dexter (for example MgS04 and Xanthan gum) resulted in an unstable or heterogeneous system in the above tested samples. Therefore, one [ of] ordinary skill in the art would not have combined Dexter with Martin to obtain the claimed homogeneous system." Id. at 10. We are not persuaded of the relevance of the Martin Declaration to the rejection presently before us. The Examiner does not rely upon, or even cite, the Dexter reference in the Final Rejection. However, Brahm expressly 13 Appeal2018-002330 Application 14/217,534 teaches combining encapsulated pesticides with non-encapsulated pyrethoid insecticides. See Brahm ,r 102. Tsuda teaches the preparation of encapsulated pesticides prepared in the same manner as claimed. We take Appellants' point that there is a level of unpredictability in the art of composing stable and homogeneous pesticide compositions, but Appellants adduce no evidence that teaches or suggests that a person of ordinary skill, relying upon the teachings of Martin, Tsuda, Brahm, and Shirley would not have had a reasonable expectation of success in successfully combining the references to arrive at Appellants' claimed composition. Issue 2 Appellants argue the Examiner erred because Shirley teaches away from the claimed invention. App. Br. 9. Analysis Appellants contend that the Examiner relies upon Shirley as a basis for including an encapsulated agent. App. Br. 9. However, Appellants argue, Shirley teaches an encapsulant that is not a polyurethane coating, i.e., the claimed invention, and that the other cited prior art references do not cure the teaching away. Id. Appellants assert that a skilled artisan would have had no guidance in choosing their encapsulant over the encapsulating materials taught by Shirley. Id. Appellants contend that the references are at least contradictory with regard to this teaching, and do not suggest the limitations of Appellants' claimed invention. Id. We do not agree. The Examiner relies upon Shirley as teaching that: "the capsules according to the instant invention are prepared with at least 14 Appeal2018-002330 Application 14/217,534 one other pesticide (co-pesticide), such as another insecticide ... which would broaden the spectrum of pest control of [the encapsulated] pesticide (a)." See Final Act. 7 (citing Shirley ,r 60). As we have explained above, the Examiner relies upon Tsuda as teaching the claimed encapsulation method which teaches the claimed polyurethane component. "A reference teaches away when "a person of ordinary skill, upon reading the reference, would be discouraged from following the path set out in the reference, or would be led in a direction divergent from the path that was taken by the applicant." In re Gurley, 27 F.3d 551, 553 (Fed. Cir. 1994 ). Although we acknowledge that Shirley teaches a different method of encapsulation than that taught by Tsuda or recited in the claims, Appellants point to no teaching of Shirley that expressly or impliedly would discourage a person of ordinary skill in the art from employing the encapsulation technique taught by Tsuda, or otherwise suggests that the Tsuda method would be unsuitable, inoperative, or otherwise inappropriate. We therefore reject Appellants' argument as lacking merit. Issue 3 Appellants argue the Examiner erred because Shirley is non- analogous art to Appellants' claimed invention. App. Br. 9. Analysis Appellants argue that Shirley is non-analogous to their claimed invention. App. Br. 9. According to Appellants, Shirley is not within the field of Appellants' endeavor. Id. Appellants contend that Shirley's field of endeavor is to create a photo-labile encapsulant, whereas Appellants' 15 Appeal2018-002330 Application 14/217,534 endeavor is to provide a stable and homogenous mixture of bifenthrin, an encapsulated crop protection, and liquid fertilizer. Id. Appellants contend that Shirley is directed to addressing a different problem than that faced by Appellants, and it cannot be considered reasonably pertinent to the claims on appeal. We disagree. Two separate tests define the scope of analogous prior art: (1) whether the art is from the same field of endeavor, regardless of the problem addressed and, (2) if the reference is not within the field of the inventor's endeavor, whether the reference still is reasonably pertinent to the particular problem with which the inventor is involved. In re Bigio, 381 F.3d 1320, 1325 (Fed. Cir. 2004). All of the references are directed generally to the field of plant pesticidal compounds, and Shirley, Tsuda, and Brahm are specifically directed to compositions of encapsulated pesticides and methods for their synthesis. See Martin Abstr., Brahm Abstr. Tsuda Abstr., Shirley Abstr. Moreover, Shirley and Brahm both teach compositions of mixtures of encapsulated and non-encapsulated pesticides for expanding the spectrum of those compositions' activities. See Shirley ,r 60, Brahm ,r 102. As such, they are all within the same field of endeavor as the claims and are analogous art. Issue 4 Appellants argue that the Examiner erred because the prior art does not teach how to form a stable and homogenous mixture as claimed by Appellants. App. Br 10. 16 Appeal2018-002330 Application 14/217,534 Analysis Appellants argue that the prior art does not teach how to form a stable and homogenous mixture as claimed by Appellants. App. Br. 10. According to Appellants, homogenous combinations of encapsulated and unencapsulated insecticidal formulations are not inherently stable and are liable to separation. Id. Appellants contend that the claimed encapsulated crop protection agent is a complex mixture, and that the encapsulation process requires the combination of: (1) an aqueous phase mixture; and, (2) a water-immiscible phase mixture comprising the crop protection agent and other additional components, wherein the combination of mixtures (1) and (2) forms a heterogeneous mixture. Id. Appellants assert that the resulting two-phase mixture comprising the crop protection agent, an aqueous phase mixture and a water-immiscible mixture is then modified by addition of several other components, including a diamine reactant to form the encapsulated mixture. Id. Appellants explain that the encapsulated mixture comprises at least three blended phases, comprising the aqueous phase, the water-immiscible phase, and the solid encapsulated crop protection agent. Id. Appellants assert that this multi-phase mixture is then mixed with (i) unencapsulated bifenthrin and (ii) liquid fertilizer. Id. According to Appellants, maintaining the stability of an insecticidal formulation after addition of such a complex mixture is neither trivial nor obvious. Id. Appellants argue that Martin does not teach or suggest that such a complex mixture could be combined with an insecticidal formulation and liquid fertilizer and remain stable, and that "conventional knowledge" would suggest otherwise. Id. 17 Appeal2018-002330 Application 14/217,534 We are not persuaded. As we have explained, Tsuda, upon which the Examiner relies, teaches the method of synthesizing encapsulated pesticides recited in the claims. See Tsuda ,r,r 29--33, 57. Appellants point to no evidence of record that these teachings of Tsuda are not enabled. Furthermore, and as we have explained, both Brahm and Shirley teach mixing encapsulated pesticides with non-encapsulated pesticides; Brahm expressly teaches combining encapsulated pesticides with pyrethoid pesticides such as bifenthrin. See Brahm ,r 102. Appellants point to no specific evidence of record that these teachings are not enabled. Appellants' assertion of non-enablement relies upon general assertions that creating such mixtures is complicated and difficult, but they point to no evidence of record demonstrating that a person of ordinary skill in the art could not follow the teachings of the cited prior art with a reasonable expectation of success beyond such generalized assertions. That is not sufficient to overcome the Examiner's primafacie case that the claims are obvious, based upon the express teachings of the prior art. Issue 5 Appellants allege that the Examiner erred by improperly relying upon hindsight analysis in arriving at a conclusion of prima facie obviousness. App. Br. 11. Analysis Appellants argue that Martin does not suggest an encapsulated crop protection agent incorporated as claimed. App. Br. 11. Appellants assert that Shirley does not suggest the polyurethane encapsulant, nor does Shirley 18 Appeal2018-002330 Application 14/217,534 suggest the combination with a liquid fertilizer. Id. Appellants contend that no other reference suggests how or why the composition claimed by Appellants should be combined in the manner claimed, and that there is therefore no basis for the combination other than Appellants' claims. We are not persuaded. The Examiner properly set forth in the Final Action, and we have explained supra, the reasons why the combined references teach all of the limitations of the claims and teach or suggest combining the references to arrive at Appellants' claimed invention. As we have explained, Martin teaches, as Appellants acknowledge, a mixture of bifenthrin and plant fertilizer, but does not teach combining it with encapsulated pesticides. Shirley teaches that mixing encapsulated and non- encapsulated pesticides is advantageous because it increases the spectrum of the compositions' activities. See Shirley ,r 60. Tsuda expressly teaches the method of synthesizing encapsulated pesticides recited in the claims. See Tsuda ,r,r 29--33, 57. Brahm also teaches mixing encapsulated and non- encapsulated pesticides, specifically including pyrethoid pesticides such as bifenthrin in the latter category. See Brahm ,r 102. The test for obviousness is not whether the features of a secondary reference may be bodily incorporated into the structure of the primary reference; nor is it that the claimed invention must be expressly suggested in any one or all of the references. Rather, the test is what the combined teachings of the references would have suggested to those of ordinary skill in the art. In re Keller, 642 F.2d 413,425 (C.C.P.A. 1981). Furthermore: Any judgment on obviousness is in a sense necessarily a reconstruction based upon hindsight reasoning, but so long as it takes into account only knowledge which was within the level of 19 Appeal2018-002330 Application 14/217,534 ordinary skill at the time the claimed invention was made and does not include knowledge gleaned only from applicant's disclosure, such a reconstruction is proper. In re McLaughlin, 443 F.2d 1392, 1395 (C.C.P.A. 1971). Appellants point to no reasoning by the Examiner that relies solely upon knowledge that could be obtained only from Appellants' Specification, and not from the prior art, beyond a mere unsupported and general assertion that such is the case. We do not find such reasoning persuasive, and we affirm the Examiner's rejection of the claims. DECISION The Examiner's rejection of claims 1-2, 5-18, and 21-22 as unpatentable under 35 U.S.C. § 103(a) is affirmed. No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a)(l )(iv). AFFIRMED 20 Copy with citationCopy as parenthetical citation