Ex Parte YanivDownload PDFPatent Trial and Appeal BoardApr 15, 201612564750 (P.T.A.B. Apr. 15, 2016) Copy Citation UNITED STA TES p A TENT AND TRADEMARK OFFICE APPLICATION NO. FILING DATE 12/564,750 0912212009 75589 7590 04/19/2016 Matheson Keys Daffer & Kordzik PLLC 7004 Bee Cave Rd. Bldg. 1, Suite 110 Austin, TX 78746 FIRST NAMED INVENTOR Zvi Yaniv UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O. Box 1450 Alexandria, Virginia 22313-1450 www .uspto.gov ATTORNEY DOCKET NO. CONFIRMATION NO. 21545-156002 9045 EXAMINER NGUYEN, BAO THUY L ART UNIT PAPER NUMBER 1600 NOTIFICATION DATE DELIVERY MODE 04/19/2016 ELECTRONIC Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the following e-mail address( es): kkordzik@mathesonkeys.com claney@mathesonkeys.com kdaffer@mathesonkeys.com PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte ZVI Y ANIV Appeal2013-004152 1 Application 12/564,750 Technology Center 1600 Before DEMETRA J. MILLS, FRANCISCO C. PRATS, and JACQUELINE T. HARLOW, Administrative Patent Judges. PRATS, Administrative Patent Judge. DECISION ON APPEAL This appeal under 35 U.S.C. § 134(a) involves claims to a field emission device that includes carbon nanotubes (CNTs) bound to a cathode by way of biological complementary binding pairs, such as biotin- streptavidin binding or DNA oligomer complementary binding. The Examiner rejected the claims for anticipation and obviousness. We have jurisdiction under 35 U.S.C. § 6(b). We affirm. 1 "The real party in interest is Applied Nanotech Holdings, Inc., which is the assignee of the entire right and interest in the present Application." App. Br. 1 (Appeal Brief entered September 6, 2012). Appeal2013-004152 Application 12/564,750 STATEMENT OF THE CASE Appellant's invention "relates in general to carbon nanotubes, and in particular, to the functionalization of carbon nanotubes." Spec. 1. The Specification explains that "[c]arbon Nanotubes (CNTs) are used in their electron emission mode for many applications. In some of these applications, the CNTs are deposited on a substrate, resulting in the field emission cathode. In their electron emission mode, the CNTs are operated at high fields, and their adherence to the cathode substrate is very important." Id. The Specification discloses that both of the principal methods used in the past to adhere CNTs to cathodes, chemical vapor deposition and ink/paste application, had certain drawbacks. Id. In Appellant's invention, in contrast, the CNTs are adhered to the cathode substrate by placing one partner of a biologically complementary binding pair on one end of a CNT, and the complementary partner on the cathode substrate, and allowing the partners to bind to each other. See id. at 4--5. The Specification discloses that biotin-streptavidin binding or DNA oligomer complementary binding may be used to adhere the CNTs to the cathode substrate. Id. The Specification discloses that, by using such strongly binding partners to attach only one end of the CNTs to the cathode substrate, "when they bend in the field they are substantially the same length, achieving in such a way a very uniform electron emission pattern, and as a result light emission uniformity from the anode." Id. at 3. 2 Appeal2013-004152 Application 12/564,750 Claims 10-14 and 17-24 stand rejected and appealed. Non-Final Act. 1 (entered April 9, 2012); App. Br. 1. The following rejections are before us for review: (1) Claims 10, 11, 13, 17, 18, and 20, under 35 U.S.C. § 102(e) as anticipated by McCall2 (Non-Final Act. 2-3); (2) Claims 10, 11, 13, 14, 17, 18, 20, and 21, under 35 U.S.C. § 102(b) as anticipated by Hamers3 (Non-Final Act. 3--4); (3) Claims 10-13, 17-20, 22, and 23, under 35 U.S.C. § 103(a) for obviousness over Takai4 and McCall (Non-Final Act. 4--6); and (4) Claims 10-14 and 17-24 under 35 U.S.C. § 103(a) for obviousness over Takai and Hamers (Non-Final Act. 6-8). 5 Claims 10, 11, 13, 14, 17, and 18 illustrate the appealed subject matter and read as follows (App. Br. 17): 10. A field emission device comprising a cathode comprising a substrate with functionalized CNTs attached thereto by way of biological complementar; binding pairs. 11. The field emission device as recited in claim 10, further comprising an anode positioned a predetermined distance from the cathode. 2 U.S. Patent Appl. Pub. No. 2006/0246438 Al (published Nov. 2, 2006). 3 U.S. Patent Appl. Pub. No. 2004/0235016 Al (published Nov. 25, 2004). 4 U.S. Patent Appl. Pub. No. 2003/0090190 Al (published May 15, 2003). 5 Although the Examiner did not include claim 24 in the initial list of claims rejected for obviousness over Takai and Hamers (Non-Final Act. 6), the Examiner explained where the features of claim 24 were found in the cited references (id. at 8), and included claim 24 in the overall list of rejected claims (id. at 1 ). 3 Appeal2013-004152 Application 12/564,750 13. The field emission device as recited in claim 10, wherein the biological complementary binding pairs comprise DNA. 14. The field emission device as recited in claim 10, wherein the biological complementary binding pairs comprise biotin and streptavidin. 1 7. A field emission device comprising a field emission cathode comprising a first substrate with functionalized CNTs attached thereto by way of biological complementary binding pairs. 18. The field emission device as recited in claim 17, further comprising a field emission anode positioned a predetermined distance from the field emission cathode. ANTICIPATION-MCCALL The Examiner found that, as required by claims 10 and 1 7, McCall discloses "electrodes comprising a substrate with functionalized CNTs attached thereto by way of biological complementary binding pairs." Final Act. 2 (citing McCall i-f 325). The Examiner noted in particular that McCall's "biological binding pairs comprise DNA." Id. at 3 (citing McCall ,-r 325). As to claim interpretation, the Examiner concluded that, "in light of the [S]pecification, the terms 'cathode' and 'field emission cathode' are not defined, and do not appear to impart any additional structural features or limitations to the claim, and therefore appear to be an intended use of the electrode." Id. at 2-3. Appellant contends that the Examiner's interpretation of claims 10 and 17 is erroneous because the Examiner ignores the fact that the preambles of those claims expressly recite a "field emission device." App. Br. 3--4, 6- 4 Appeal2013-004152 Application 12/564,750 7. Appellant contends also that the Examiner's interpretation of the claim terms "field emission device," "cathode," and "anode" is unreasonably broad because the Examiner did not properly interpret the claims in light of the relevant disclosures in the Specification. App. Br. 3-7; Reply Br. 1-2. The Examiner responds that the Specification "specifically discloses that 'the CNTs are deposited on a substrate resulting in the field emission cathode' (p. 1, lines 10-15 of the specification), as applicants themselves have acknowledged in the appeal brief(see p. 5, lines 5-10)." Ans. 10. The Examiner contends also that "the term 'cathode' is defined in the art as 'the negatively charged electrode by which electrons enter an electrical device'. Absent a source of electrons or a voltage or current source, as currently recited in claims 10 and 17, a 'cathode' is an electrode." Ans. 10. As stated in Jn re Oetiker, 977 F.2d 1443, 1445 (Fed. Cir. 1992): [T]he examiner bears the initial burden . . . of presenting a prima facie case of unpatentability .... i~\'.l.fter evidence or argument is submitted by the applicant in response, patentability is determined on the totality of the record, by a preponderance of evidence with due consideration to persuasiveness of argument. Appellant's arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case as to claims 10 and 1 7. In particular, Appellant does not persuade us that, in finding that claims 10 and 17 encompass the device described in McCall, the Examiner interpreted claims 10 and 17 unreasonably broadly. We acknowledge, as Appellant argues (App. Br. 3-7), that claims 10 and 17 both plainly recite "[a] field emission device" (id. at 17). We acknowledge also that Appellant's Figure 6 is described as depicting "a field 5 Appeal2013-004152 Application 12/564,750 emission device." Spec. 2. We acknowledge, as noted above in our summary of the Specification's disclosure, and as Appellant argues (App. Br. 5), that the objective of Appellant's invention is improved electron emission uniformity (see Spec. 3). As our reviewing court has explained, however, "while 'the specification [should be used] to interpret the meaning of a claim,' courts must not 'import[ ] limitations from the specification into the claim.' ... [I]t is improper to 'confin[ e] the claims to th[ e] embodiments' found in the specification .... " In re Trans Texas Holdings Corp., 498 F.3d 1290, 1299 (Fed. Cir. 2007) (quoting Phillips, 415 F.3d at 1323 (citations omitted, bracketed text in internal quotes in original). Ultimately therefore, "absent claim language carrying a narrow meaning, the PTO should only limit the claim based on the specification ... when [it] expressly disclaims the broader definition." In re Bigio, 381 F.3d 1320, 1325 (Fed Cir. 2004); see also, In re Paulsen, 30 F.3d 1475, 1480 (Fed. Cir. 1994) ("Although an inventor is indeed free to define the specific terms used to describe his or her invention, this must be done with reasonable clarity, deliberateness, and precision."). In the instant case, Appellant does not direct us to a specific definition of the term "field emission device" or "cathode" in the Specification. Accordingly, given the directives from Trans Texas, Bigio, and Paulsen, that limitations should not be imported into the claims from the Specification, absent specific claim language and an express disclaimer or definition of the claim term at issue, Appellant does not persuade us that the interpretation of "field emission device" is reasonably limited to the device shown in Figure 6, or a device having the elements depicted in that figure. Nor are we 6 Appeal2013-004152 Application 12/564,750 persuaded, for the same reasons, that the Examiner was unreasonable in declining to limit the interpretation of "cathode" to the applications described in the Specification. Our reviewing court has noted also that, "during patent prosecution when claims can be amended, ambiguities should be recognized, scope and breadth of language explored, and clarification imposed." In re Zietz, 893 F.2d 319, 321 (Fed. Cir. 1989). In the instant case, despite Appellant's assertion that a skilled artisan would understand a field emission device to fundamentally include both a cathode and an anode (App. Br. 7), Appellant does not direct us to a clear or specific definition of "field emission device" on the current record supporting that assertion. Although Appellant intimates that the discussion in paragraph 3 of Takai suggests that a field emission device includes a cathode, anode, and voltage source (App. Br. 3), Appellant does not state affirmatively whether that disclosure in Takai presents an art-accepted definition or characterization of the term. The ambiguity in Appellant's proffered claim interpretation is underscored by the fact that the claims themselves, under the doctrine of claim differentiation, support the Examiner's contention that, given the current record, the term "field emission device" as used in claims 10 and 17 encompasses devices that include only the cathode recited in those claims. Specifically, despite Appellant's assertion that a field emission device as recited necessarily includes both an anode and a cathode, claims 10 and 17 do not require the device to include an anode, and the allegedly required anode first appears in dependent claims 11and18. See App. Br. 17. 7 Appeal2013-004152 Application 12/564,750 Appellant has not established that the doctrine of claim differentiation, or an exception to it, does not apply to the interpretation of claims 10 and 17. Appellant, moreover, does not explain clearly or specifically why the device in McCall identified by the Examiner fails to include all features of claims 10 and 17, even assuming for argument's sake that the device recited in claims 10 and 1 7 necessarily includes the features shown in Appellant's Figure 6. As the Examiner points out, and as required by each of claims 10 and 17, McCall describes CNTs attached to a substrate by way of complementary DNA binding: Using a mask, single-stranded DNA molecules (pre- made, with thiol linker) are spotted on to the gold electrodes in the desired locations. The mask is removed, and the chip is dipped into MAAD (mercapto-acetic-acid dimer) to cover remaining gold surfaces with a negatively charged self- assembled monolayer. The carbon nanotubes are positioned across the gold electrodes using hybridization between the DNA on the modified nanotubes and their complementary DNA molecules bound to the gold electrodes. McCall i-f 325 (emphasis added). Like the device shown in Appellant's Figure 6, in the embodiment identified by the Examiner, the bound CNTs are disposed between two electrodes, with an electrical current, that is electrons, passing from one electrode to the other, through the CNTs. See McCall i-f 320 ("This experiment demonstrates the use of DNA to precisely locate carbon nanotubes between two gold electrodes, and to measure the current-voltage properties of this completed, self-assembled circuit.") (emphasis added); id. at i-f 327 ("Current-voltage curves for the two-electrode system spanned by a nanotube or group of nanotubes are measured. The measurements are 8 Appeal2013-004152 Application 12/564,750 repeated for the control where two electrodes are not spanned by a nanotube. "). As to one of the two electrodes of McCall's device being the cathode required by claims 10 and 17, as noted above, the undisputed art-accepted meaning of cathode advanced by the Examiner is the negatively charged electrode by which electrons enter an electrical device. As noted, McCall discloses applying a voltage to its device, thereby allowing an electrical current to enter the device, passing electrons through the CNTs from one electrode to the other. McCall i-fi-1 320, 327. Thus, we are not persuaded that Appellant explains with adequate specificity which features of claims 10 and 17 are missing from the McCall's device. In sum, for the reasons discussed, Appellant's arguments do not persuade us that the Examiner interpreted claims 10 and 17 unreasonably broadly, nor do Appellant's arguments persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case that McCall describes a device having all of the features required by claims 10 and 17. Accordingly, we affirm the Examiner's rejection of claims 10 and 17 as anticipated by McCall. Because they were not argued separately, claims 11, 13, 18, and 20 fall with claims 10 and 17. 37 C.F.R. § 41.37(c)(iv). ANTICIPATION-HAMERS The Examiner found that, as required by claims 10 and 1 7, Hamers discloses "electrodes comprising a substrate with functionalized CNTs attached thereto by way of biological complementary binding pairs." Final Act. 3 (citing Hamers i-fi-f 15-17). The Examiner noted in particular that Hamers discloses biological binding pairs which can be either DNA or biotin and streptavidin. Id. at 4 (citing Hamers i-fi-1 20, 21 ). 9 Appeal2013-004152 Application 12/564,750 As with McCall, discussed above, the Examiner concluded that, "in light of the [S]pecification, the terms 'cathode' and 'field emission cathode' are not defined, and do not appear to impart any additional structural features or limitations to the claim, and therefore appear to be an intended use of the electrode." Id. at 3. Appellant contends that Hamers does not disclose a field emission device, and incorporates by reference the arguments made in traversal of the Examiner's anticipation rejection over McCall. App. Br. 7-8. For essentially the same reasons discussed above as to McCall, Appellant's arguments do not persuade us that the Examiner interpreted claims 10 and 17 unreasonably broadly, nor do Appellant's arguments persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case that Hamers describes a device having all of the features required by claims 10 and 1 7. As noted above, given the directives from In re Trans Texas Holdings, 498 F.3d at 1299, In re Bigio, 381 F.3d at 1325, and In re Paulsen, 30 F.3d 1475, 1480, Appellant does not persuade us that the interpretation of "field emission device" is reasonably limited to the device shown in Figure 6, or a device having the elements depicted in that figure. Nor are we persuaded, for the same reasons, that the Examiner was unreasonable in declining to limit the interpretation of "cathode" to the applications described in the Specification. Appellant, moreover, does not explain clearly or specifically why the device in Hamers identified by the Examiner fails to include all features of claims 10 and 17, even assuming for argument's sake that the device recited 10 Appeal2013-004152 Application 12/564,750 in claims 10 and 1 7 necessarily includes the features shown in Appellant's Figure 6. As the Examiner points out, and as required by each of claims 10 and 17, Hamers describes a device including CNTs attached to a substrate by way of biological complementary binding: One embodiment of a bioswitch that acts as a biomolecular sensor for detecting the presence of an analyte may be constructed from two electrodes and a nanocylinder, such as a nanotube. Specifically, the bioswitch includes: (a) a first electrode having at least one biomolecule bound thereto; (b) a second electrode having at least one biomolecule bound thereto, wherein the first and second electrodes are separated by a gap; (c) a nanocylinder having at least two biomolecules bound thereto; and (d) a detector connected to the first and second electrodes for measuring the impedance between the first and second electrodes. In this configuration, the at least one biomolecule bound to the first electrode and one of the at least two biomolecules bound to the nanocylinder are capable of binding the analyte between them and the at least one biomolecule bound to the second electrode and the other of the at least two biomolecules bound to the nanocylinder are capable of binding the analyte between them, such that the nanocylinder bridges the gap between the first and second electrodes and modifies the electrical impedance (i.e. resistance, capacitance, or inductance, or a combination thereof) between the first and second electrodes. Hamers i-f 15 (emphasis added). Like the device shown in Appellant's Figure 6, in the device in Hamers identified by the Examiner, the bound CNTs are disposed between two electrodes, with an electrical current, that is electrons, passing from one electrode to the other, through the CNTs. As to one of the two electrodes of Hamers' s device being the cathode required by claims 10 and 17, as noted 11 Appeal2013-004152 Application 12/564,750 above, the undisputed art-accepted meaning of cathode advanced by the Examiner is the negatively charged electrode by which electrons enter an electrical device. As is evident, Hamers discloses applying a voltage to its device, thereby allowing an electrical current to enter the device, passing electrons through the CNTs from one electrode to the other. Thus, we are not persuaded that Appellant explains with adequate specificity which features of claims 10 and 17 are missing from the Hamers' s device. In sum, for the reasons discussed, Appellant's arguments do not persuade us that the Examiner interpreted claims 10 and 17 unreasonably broadly, nor do Appellant's arguments persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case that Hamers describes a device having all of the features required by claims 10 and 17. Accordingly, we affirm the Examiner's rejection of claims 10 and 17 as anticipated by Hamers. Because they were not argued separately, claims 11, 13, 14, 18, 20, and 21 fall with claims 10 and 17. 37 C.F.R. § 41.37(c)(iv). OBVIOUSNESS-TAKAI AND MCCALL In rejecting claims 10-13, 17-20, 22, and 23, for obviousness over Takai and McCall, the Examiner cited Takai as disclosing a field emission device having all of the claimed features, including CNTs attached to a cathode substrate, but conceded that Takai did not "specify that the chemically treated carbon nanotubes are attached to the cathode by biological complementary binding pairs." Non-Final Act. 5. To address that deficiency, the Examiner cited McCall as disclosing the use of complementarily hybridizing nucleic acid oligomers as a technique of 12 Appeal2013-004152 Application 12/564,750 binding CNTs to substrates in electronic devices, which "allows for nanotubes to be directed toward specific locations." Id. (citing McCall i-f 8). Based on the references' teachings, the Examiner concluded that an ordinary artisan would have considered it obvious to "have utilized biological complementary binding pairs such as the DNA-directed assembly of McCall et al to attach the carbon nanotubes of Takai et al. to the substrate, in order to provide a means for nanotubes to be directed toward specific locations for attachment." Id. We select claim 10 as representative of the rejected claims. 37 C.F.R. § 41.37(c)(iv). Appellant's arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 1 0. As required by claim 10, and as the Examiner found, Takai discloses field emission devices with field emission cathodes composed of CNTs bound to a substrate. Takai i-f 15 ("[T]he field emission display-device comprises a first substrate, a first metal film on said first substrate; a conductive polymer film on said first metal film, said conductive polymer film including emitter tips comprising carbon nanotubes .... "); see also id. at i-f 12 ("The carbon nanotubes may form the cathode or may be deposited onto a substrate to form the cathode."). As the Examiner found also, Takai discloses the desirability of adhering the CNTs to specific desired locations on the substrate, in the form of patterns. Id. at i-f 77 ("In addition to electrophoresis, other processes such as screen printing can be used for creating the patterns. . . . In addition to screen printing, the carbon nanotubes can be applied to a substrate by inkjet 13 Appeal2013-004152 Application 12/564,750 printing."); see also id. at il 81 ("In yet another method, fibril based inks can be formulated for use in spray equipment. When combined with a masking technology, spray painting of fibril based inks offers a suitable method for depositing fibril ink patterns of either simple or complex designs."). Although it might be true that Takai differs from claim 10 in that Takai does not use complementary pair binding to attach its CNTs to its substrates, McCall discloses that its technique of using biological complementary pairs of DNA oligomers to adhere CNTs to substrates allows placement of the CNTs at specific locations, as the Examiner found. McCall i-f 7 ("The inventors have also developed a method for locating nanotubes to specific targets. The inventors have also developed techniques which allow DNA patterning on nanotubes as well as the creation of multiple layers of nanoparticles on the surface of nanotubes."); id. at i-f 8 ("[T]he invention provides a process whereby nanotubes may be directed to specific locations."). Given Takai's disclosure of the desirability of attaching the CNTs in its field emissions devices to specific locations on substrates, and further given McCall's disclosure that its technique of using biological complementary pairs of DNA oligomers to adhere CNTs to substrates allows placement of the CNTs at specific locations, the result desired by Takai, we agree with the Examiner that an ordinary artisan would have been prompted to prepare Takai's device using the attachment method described in McCall, thereby producing the device recited in claim 10. Given the discussed teachings, moreover, we are not persuaded that Takai and McCall, taken together, would have failed to motivate an ordinary artisan to prepare Takai's device using the attachment method described in 14 Appeal2013-004152 Application 12/564,750 McCall, thereby producing the device recited in claim 10, as Appellants argue. App. Br. 8-9; Reply Br. 2-3. In addition, because the teachings suggesting the claimed device are derived only from the cited prior art, Appellant's arguments (App. Br. 8-11; Reply Br. 3--4) do not persuade that the Examiner's conclusion of obviousness is based solely on improper hindsight gleaned from Appellant's Specification. As to Appellant's argument that McCall is not analogous art to the claimed invention, which is field emission devices (Reply Br. 3), we first note that this argument is improperly made for the first time in the Reply Brief. See 37 C.F.R. § 41.41(b)(2). In any event, McCall discloses in its background section that CNTs "have been proposed as new materials for electron field emitters in panel displays." McCall i-f 3. Given this disclosure, and given, as discussed above, that McCall is directed to attaching CNTs to substrates for use in electronic devices, precisely the pursuit in Takai, we are not persuaded that McCall is non-analogous art to the invention recited in claim 10. In sum, for the reasons discussed, Appellant's arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 10. Because Appellant does not advance secondary evidence of nonobviousness to rebut the Examiner's prima facie case, we affirm the Examiner's obviousness rejection of claim 10 over Takai and McCall. Because they were not argued separately, claims 11-13, 17-20, 22, and 23 fall with claim 10. 37 C.F.R. § 41.37(c)(iv). 15 Appeal2013-004152 Application 12/564,750 OBVIOUSNESS--'TAKAI AND HAMERS In rejecting claims 10-14 and 17-24 for obviousness over Takai and Hamers, the Examiner again cited Takai as disclosing a field emission device having all of the claimed features, including CNTs attached to a cathode substrate, and again conceded that Takai did not "specify that the chemically treated carbon nanotubes are attached to the cathode by biological complementary binding pairs." Non-Final Act. 6. To address that deficiency, the Examiner cited Hamers as teaching attachment of CNTs "through biomolecular interactions between biomolecules on the nanocylinders and biomolecules bound to a surface" which "allows for the controlled attachment of nanocylinders to the surface and [is] therefore useful in a range of applications, such as electronic devices." Id. (citing Hamers i-fi-17-13). The Examiner noted in particular Hamers's teaching that the biological complementary binding technique "allows for covalent linkages that are chemically and thermally stable, and .. . minimize the disruption of the structure and electronic properties of the nanocylinders (para. 0011, 0013)." Id. Based on the references' teachings, the Examiner concluded: [I]t would have been obvious to one of ordinary skill in the art at the time of the invention to have utilized biological complementary binding pairs to attach nanocylinders such as the carbon nanotubes of Takai et al. to the cathode, in order to allow for the controlled attachment of nanocylinders to the surface, which would be useful in a range of applications, such as electronic devices, by providing linkages that are chemically and thermally stable and which would minimize the disruption of the structure and electronic properties of the CNTs of Takai et al. Id. at 6-7. 16 Appeal2013-004152 Application 12/564,750 We select claim 10 as representative of the rejected claims. 37 C.F.R. § 41.37(c)(iv). Appellant's arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 1 0. As noted above, as required by claim 10, and as the Examiner found, Takai discloses field emission devices with field emission cathodes composed of CNTs bound to a substrate. Takai i-fi-f 12, 15. As the Examiner found also, and as discussed above, Takai discloses the desirability of adhering the CNTs to specific desired locations on the substrate, in the form of patterns. Id. at i177, 81. It might be true that Takai differs from claim 10 in that Takai does not use biological complementary pair binding to attach its CNTs to its substrates. As the Examiner found, however, Hamers discloses a number of advantages of the technique of using biological complementary binding pairs to adhere CNTs to substrates, including chemical and thermal stability, as well as placement of the CNTs at specific locations for use in electronic devices. Hamers i-f 11 ("In certain embodiments, the biomolecules are covalently linked to the nanocylinder(s). This is advantageous because covalent linkages make the nanocylinder-biomolecule adducts chemically and thermally stable ... . ");see also id. at i-f 13: The ability to control the placement of nanocylinders on a substrate allows for the production of patterned surfaces where the nanocylinders are laid out relative to one another in a predetermined design. The patterned surfaces are useful for many applications, including nanoelectronic circuits. In addition, the controlled assembly of nanocylinders on surfaces allows for the production of a variety of electronic devices and 17 Appeal2013-004152 Application 12/564,750 sensors, including devices constructed from assemblies of one or more nanocylinders and one or more surfaces bound by biomolecular interactions between complementary biomolecule pairs. Given Takai's disclosure of the desirability of attaching the CNTs in its field emissions devices to specific locations on substrates, and further given Hamers' s disclosure of the advantages of its technique, particularly the placement of the CNTs at specific locations in a patterned arrangement, precisely the result desired by Takai, we agree with the Examiner that an ordinary artisan would have been prompted to prepare Takai' s device using the attachment method described in Hamers, thereby producing the device recited in claim 10. Given the discussed teachings, moreover, we are not persuaded that Takai and Hamers, taken together, would have failed to motivate an ordinary artisan to prepare Takai's device using the attachment method described in Hamers, thereby producing the device recited in claim 10, as Appellants argue. App. Br. 11-12, 15-16; Reply Br. 2-3. In addition, because the teachings suggesting the claimed device are derived only from the cited prior art, Appellant's arguments (App. Br. 12-14; Reply Br. 3--4) do not persuade that the Examiner's conclusion of obviousness is based solely on improper hindsight gleaned from Appellant's Specification. As to Appellant's argument that Hamers is not analogous art to the claimed invention, which is field emission devices (Reply Br. 3), we first note that this argument is improperly made for the first time in the Reply Brief. See 37 C.F.R. § 41.41(b)(2). In any event, Hamers discloses in its background section that "there has been a tremendous interest in the use of 18 Appeal2013-004152 Application 12/564,750 carbon nanotubes and related nano-sized objects in electronic devices,field emission sources, and chemical sensors." Hamers i-f 4 (emphasis added). Given this disclosure, and given, as discussed above, that Hamers is directed to attaching CNTs in patterned arrangements to substrates for use in electronic devices, precisely the pursuit in Takai, we are not persuaded that Hamers is non-analogous art to the invention recited in claim 10. In sum, for the reasons discussed, Appellant's arguments do not persuade us that a preponderance of the evidence fails to support the Examiner's prima facie case of obviousness as to claim 10. Because Appellant does not advance secondary evidence of nonobviousness to rebut the Examiner's prima facie case, we affirm the Examiner's obviousness rejection of claim 10 over Takai and Hamers. Because they were not argued separately, claims 11-14 and 17-24 fall with claim 10. 37 C.F.R. § 41.37(c)(iv). CONCLUSION For the reasons discussed, we affirm the Examiner's rejection of claims 10, 11, 13, 17, 18, and 20, under 35 U.S.C. § 102(e) as anticipated by McCall. For the reasons discussed, we also affirm the Examiner's rejection of claims 10, 11, 13, 14, 17, 18, 20, and 21, under 35 U.S.C. § 102(b) as anticipated by Hamers. For the reasons discussed, we also affirm the Examiner's rejection of claims 10-13, 17-20, 22, and 23, under 35 U.S.C. § 103(a) for obviousness over Takai and McCall. 19 Appeal2013-004152 Application 12/564,750 For the reasons discussed, we also affirm the Examiner's rejection of claims 10-14 and 17-24 under 35 U.S.C. § 103(a) for obviousness over Takai and Hamers. No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a). AFFIRMED 20 Copy with citationCopy as parenthetical citation