Ex Parte GeorgopoulosDownload PDFPatent Trial and Appeal BoardAug 22, 201713312332 (P.T.A.B. Aug. 22, 2017) Copy Citation United States Patent and Trademark Office UNITED STATES DEPARTMENT OF COMMERCE United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS P.O.Box 1450 Alexandria, Virginia 22313-1450 www.uspto.gov APPLICATION NO. FILING DATE FIRST NAMED INVENTOR ATTORNEY DOCKET NO. CONFIRMATION NO. 13/312,332 12/06/2011 Apostolos Georgopoulos Z09185/U639.104.102 9191 25281 7590 DICKE, BILLIG & CZAJA FIFTH STREET TOWERS 100 SOUTH FIFTH STREET, SUITE 2250 MINNEAPOLIS, MN 55402 EXAMINER FERNANDEZ, KATHERINE L ART UNIT PAPER NUMBER 3768 NOTIFICATION DATE DELIVERY MODE 08/24/2017 ELECTRONIC Please find below and/or attached an Office communication concerning this application or proceeding. The time period for reply, if any, is set in the attached communication. Notice of the Office communication was sent electronically on above-indicated "Notification Date" to the following e-mail address(es): USPTO.PATENTS @dbclaw.com dmorris@dbclaw.com DBCLAW-Docket@dbclaw.com PTOL-90A (Rev. 04/07) UNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Ex parte APOSTOLOS GEORGOPOULOS1 Appeal 2016-007620 Application 13/312,332 Technology Center 3700 Before ERIC B. GRIMES, JOHN G. NEW, and TIMOTHY G. MAJORS, Administrative Patent Judges. NEW, Administrative Patent Judge. DECISION ON APPEAL 1 Appellant states the real parties-in-interest are the Regents of the University of Minnesota and the Department of Veterans Affairs. App. Br. 3. Appeal 2016-007620 Application 13/312,332 SUMMARY Appellant files this appeal under 35 U.S.C. § 134(a) from the Examiner’s Final Rejection of claims 1-20.2 The Appellant disputes the Examiner’s interpretation of claim 10 under 35 U.S.C. § 112, sixth paragraph. Specifically, claim 10 stands rejected as unpatentable under 35 U.S.C. § 112, sixth paragraph, because the claim uses a generic placeholder, coupled with functional language, without reciting sufficient structure to achieve the function. Claims 1-20 stand rejected as unpatentable under 35 U.S.C. § 101 as being directed to nonstatutory subject matter. Claims 1-3, 6, 10, 11, 14, and 18 stand rejected as being unpatentable under 35 U.S.C. § 103(a) as being obvious over the combination of John (US 4,188,956, February 19, 1980) (“John”), Hay (US 7,110,582 Bl, September 19, 2006) (“Hay”), and John (US 4,846,190, July 11, 1989) (“John ’190”). Claims 7, 9, 15, 17, and 20 stand rejected as unpatentable under 35 U.S.C. § 103(a) as being obvious over the combination of John, Hay, John ’190, and J.V. Selinger et al., Measuring Synchronization in Neuronal Networks for Biosensor Applications, 19 Biosensors and Bioelectronics 675-683, 2004 (“Selinger”). Claims 8, 16, and 19 stand rejected as unpatentable under 35 U.S.C. § 103(a) as being obvious over the combination of John, Hay, John ’190, 2 Claims 1-20 were also rejected as unpatentable under 35 U.S.C. 112, second paragraph, as being indefinite. Final Act. 5. The Examiner has withdrawn this rejection. Ans. 2. 2 Appeal 2016-007620 Application 13/312,332 and Georgopoulos et al. (US 2008/0091118 Al, April 17, 2008) (“Georgopoulos”). We have jurisdiction under 35 U.S.C. § 6(b). We AFFIRM. NATURE OF THE CLAIMED INVENTION Appellant’s invention is directed to a computer-implemented method for performing a functional assessment of a network. Abstract. REPRESENTATIVE CLAIM Claim 1 is representative of the claims on appeal, and recites: 1. A computer-implemented method for performing a functional assessment of a network, the network including a plurality of interacting network elements, the method comprising: measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements; calculating for each element an associated median value that is a median of the state values associated with that element; identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the elements with an associated state value at that time instance that is below its associated median value; and 3 Appeal 2016-007620 Application 13/312,332 determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. App. Br. 22. ISSUES AND ANALYSES Except where otherwise indicated, we adopt the Examiner’s findings and conclusions that certain claims are obvious over the cited prior art. We address Appellant’s arguments below. A. Interpretation of claim 10 under 35 U.S.C. $ 112, sixth paragraph Independent claim 10 recites (emphasis added): 10. A system for performing a functional assessment of a network, the network including a plurality of interacting network elements, the system comprising: a network element state measurement unit to measure a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements; and a controller configured to calculate for each element an associated median value that is a median of the state values associated with that element, identify for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the elements with an associated state value at that time instance that is below its associated median value, and determine whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. App. Br. 23. 4 Appeal 2016-007620 Application 13/312,332 The Examiner finds claim 10 uses the generic placeholder “unit” coupled with the functional language “configured to measure a state of each of the elements ..without reciting sufficient structure to achieve the function. Final Act. 2. Furthermore, the Examiner finds, the generic placeholder is not preceded by a structural modifier: specifically, the Examiner finds that the term “network element state measurement” is not a structural modifier as the term does not connote structure. Id. The Examiner concludes that because the claim limitations invoke 35 U.S.C. §112, sixth paragraph, claim 10 has been interpreted to cover the corresponding structure described in Appellant’s Specification that achieves the claimed function, and equivalents thereof. Id. The Examiner points to paragraphs [0021 ]—[0023] of Appellant’s Specification as disclosing the structure corresponding to claim 10. Final Act. 2-3. The Examiner interprets the “network element measurement unit” as corresponding to a device that records neural activity, such as a multi electrode array (“MEA”) or a magnetoencephalography (“MEG”) device, and equivalents thereof. Id. Appellant argues that, as an initial matter, claim 10 does not recite a “network element state measurement unit configured to measure ....”, as stated by the Examiner but, rather, recites “network element state measurement unit to measure ....” App. Br. 6. Appellant points out that the limitations of claim 10 therefore do not recite any of the functional terms listed by MPEP § 2181. Id. at 6-7. Appellant also argues that the Examiner finds that the term “network element state measurement” is considered to be a non-structural modifier, however, Appellant contends, the Examiner has not provided any support for 5 Appeal 2016-007620 Application 13/312,332 this finding. App. Br. 7. According to Appellant, the language “network element state measurement” structurally limits the types of units that will satisfy the claim language; Appellant argues that there are many examples of units that would not structurally be considered a network element state measurement unit. Id. The Examiner finds, contrary to Appellant’s assertion, that the claim term “network element state measurement” fails to structurally limit the types of units. Ans. 10. The Examiner finds § 2181 (1)(C) of the MPEP states, in relevant part: By contrast, a generic placeholder (e.g., “mechanism,” “element,” “member”) coupled with a function may invoke . . . 35 U.S.C. § 112, sixth paragraph when it is preceded by a non- structural modifier that does not have any generally understood structural meaning in the art (e.g., “colorant selection mechanism,” “lever moving element,” or “movable link member”) To determine whether a word, term, or phrase coupled with a function denotes structure, examiners should check whether: (1) the specification provides a description sufficient to inform one of ordinary skill in the art that the term denotes structure; (2) general and subject matter specific dictionaries provide evidence that the term has achieved recognition as a noun denoting structure; and (3) the prior art provides evidence that the term has an art-recognized structure to perform the claimed function. Id. at 11 (citing Ex parte Rodriguez, 92 USPQ2d 1395, 1404 (BPAI 2009) (precedential)). With respect to these requirements of MPEP §2181, the Examiner finds: (1) Appellant’s Specification provides no definition for the term “network element state measurement” and, as such, does not provide a description sufficient to inform one of ordinary skill in the art that the term 6 Appeal 2016-007620 Application 13/312,332 denotes structure; (2) the term “network element state measurement” has no dictionary definition that provides evidence that the term has achieved recognition as a noun denoting structure; and (3) the term “network element state measurement” has no generally understood meaning in the prior art that provides evidence that the term has an art-recognized structure to perform the claimed function. Ans. 11-12. Therefore, the Examiner finds, the claim term “network element state measurement” is considered to be a non- structural modifier of the generic placeholder “unit” because the term does not connote sufficient structure to a person of ordinary skill in the art to avoid the requirements of 35 U.S.C. § 112, sixth paragraph. Id. at 11. Furthermore, the Examiner finds, the non-structural generic placeholder “unit” is listed as one of the examples of generic placeholders that may invoke 35 U.S.C. 112, sixth paragraph, interpretation. Ans. 12. The Examiner also finds part B of the 3-prong analysis established by MPEP §2181 requires that “the term ‘means’ or ‘step’ or the generic placeholder is modified by functional language, typically, but not always linked by the transition word ‘for’ (e.g., ‘means for’) or another linking word or phrase, such as ‘configured to’ or ‘so that.’” Id. (emphasis omitted). The Examiner notes that the above limitation clearly modifies the generic placeholder “unit” with functional language (i.e., “measure a state of each of the elements”) via the transition word “to” and further, the generic placeholder “unit” is not modified by sufficient structure, material, or acts for performing the claimed function, because the term “network element state measurement” is a non-structural modifier. As such, the Examiner finds, the limitation meets the 3-prong analysis of MPEP § 2181 (1)(C). Id. 7 Appeal 2016-007620 Application 13/312,332 Appellant replies that the language “network element state measurement” structurally limits the types of units that will satisfy the claim language. Reply Br. 3. According to Appellant, the disclosures of Appellant’s Specification describe these terms and provide examples (i.e., MEAs and MEGs), the dictionary definitions of these nouns, and the general understanding of these terms by persons of ordinary skill in the art provide sufficient structural limitation to the claim term “unit.” Id. We are not persuaded by Appellant’s arguments. The sixth paragraph of Section 112 (pre-AIA) recites: An element in a claim for a combination may be expressed as a means or step for performing a specified function without the recital of structure, material, or acts in support thereof, and such claim shall be construed to cover the corresponding structure, material, or acts described in the specification and equivalents thereof. Section 112 will apply if the claim term fails to “recite[ ] sufficiently definite structure” or else recites “function without reciting sufficient structure for performing that function.” Watts v. XL Sys., Inc., 232 F.3d 877, 880 (Fed. Cir. 2000). See Ex parte Rodriguez, 92 USPQ2d 1395, 1404 (BPAI2009) (precedential) (“The standard is whether the words of the claim are understood by persons of ordinary skill in the art to have a sufficiently definite meaning as the name for structure”); see also Williamson v. Citrix Online, LLC, 792 F.3d 1339, 1349 (Fed. Cir. 2015). Appellant first appears to argue that the sixth paragraph of Section 112 does not apply because it does not recite a “network element state measurement unit configured to measure ....,” as stated by the Examiner but, rather, recites “network element state measurement unit to measure ....” See App. Br. 6. We do not find Appellant’s argument persuasive, because claim 8 Appeal 2016-007620 Application 13/312,332 10 recites: “a network element state measurement unit to measure a state of each of the elements at a plurality of time instances.” Appellant’s Specification provides no explicit definition of the term “network element state measurement unit.” We also agree with the Examiner that the use of the claim term “unit” constitutes a non-structural generic placeholder such that “unit to measure” is essentially the equivalent of “unit for measuring” or “unit configured to measure,” i.e., a non-structural generic placeholder that invokes 35 U.S.C. § 112, sixth paragraph. See Mass. Inst, of Tech. v. Abacus Software, 462 F.3d 1344, 1354 (Fed. Cir. 2006) (Generic terms such as “mechanism,” “element,” “device,” and other “nonce” words that reflect nothing more than verbal constructs may be used in a claim in a manner that is tantamount to using the word “means” because they “‘typically do not connote sufficiently definite structure’” and therefore may invoke § 112, paragraph 6); see also generally MPEP § 2181 (1)(A). We consequently agree with the Examiner that the claim language recites a generic placeholder for performing the recited function of measuring (“to measure”) a state of each of the elements at a plurality of time instances, and thus interpretation under the sixth paragraph of Section 112 is invoked. We next turn to the Specification for the corresponding structure for performing the specified function. The Examiner points to paragraphs [0021 ]—[0023 ] of Appellant’s Specification as disclosing the structure corresponding to claim 10’s function, and Appellant does not dispute this finding. These paragraphs disclose, in relevant part: Figure 2 is a block diagram illustrating a system 200 for assessing the functional status of a network according to one embodiment. System 200 includes a measurement unit 202 and a controller 206. Measurement unit 202 is configured to measure 9 Appeal 2016-007620 Application 13/312,332 a state or property of elements in a network at a plurality of instances in time, thereby generating a plurality (e.g., a time series) of measured values 204 for each such element. Measurement unit 202 provides the measured values 204 to controller 206 for processing. In one embodiment, measurement unit 202 includes at least one multielectrode array (MEA) that records neural activity of a network, such as cultured embryonic tissue from a rat brain. The MEAs used in one embodiment have dimensions of 1.4 x 1.4 mm and contain an array of 60 electrodes on a flat surface, surrounded by a circular wall that creates a well around the electrodes. The electrodes are embedded in the MEA surface and are arranged in a square grid. The electrodes are titanium nitride disks of 30 pm in diameter, spaced at 200 pm intervals. One application in the field of biomagnetism involves the measurement of human brain activity, such as with a magnetoencephalography (MEG) device. A MEG device measures magnetic fields produced by electrical activity in the brain. In one embodiment, measurement unit 202 includes a MEG device with tens or hundreds of sensors, such as “SQUIDS”. A SQUID (Superconducting Quantum Interference Device) is a superconducting device for detecting magnetic fields. A SQUID, along with its associated feedback electronics, provides an output voltage proportional to the magnetic flux applied to its detection coil. Therefore, Appellant’s Specification provides different embodiments of the “measurement unit 202” (i.e., MEAs and MEGs). The Specification discloses that the measurement unit 202 “is configured to measure a state or property of elements in a network at a plurality of instances in time, thereby generating a plurality (e.g., a time series) of measured values 204 for each such element.” Spec. ^ 21. We thus agree with the Examiner and conclude that paragraphs [0021 ]—[0023] of Appellant’s Specification identify the 10 Appeal 2016-007620 Application 13/312,332 structure corresponding to the function recited in claim 10 under § 112, sixth paragraph. Claim 10 is thus interpreted to include these structures and equivalents thereof. B. Rejection of claims 1-20 under 35 U.S.C. $ 101 Issue Appellant argues the Examiner erred in concluding that the claims are directed to nonstatutory subject matter because they are impermissibly directed to the abstract idea of performing abstract processing functions. App. Br. 8. Analysis The Examiner finds that claims 1-20 are directed to the abstract idea of performing abstract processing functions, such as “measuring,” “calculating,” “identifying,” etc. Final Act. 6. The Examiner finds the additional elements, or combination of elements in the claims, other than those reciting these abstract ideas amount to no more than mere instructions to implement the idea on a computer. Id. The Examiner finds that, when viewed as a whole, these latter portions of the claims do not provide meaningful limitations so as to transform the abstract idea into a patent- eligible application of the abstract idea such that the claims amount to significantly more than the abstract idea itself. Id. Appellant argues the claims are not directed to the abstract idea “of performing abstract processing functions,” but go beyond merely reciting an abstract idea and providing an instruction to apply the abstract idea. App. Br. 8. Appellant points, by way of example, to claim 1, which, Appellant argues, 11 Appeal 2016-007620 Application 13/312,332 is directed to a computer-implemented method for performing a functional assessment of a network that includes a plurality of interacting network elements, and recites several detailed method steps, including: (1) measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements; (2) calculating for each element an associated median value that is a median of the state values associated with that element; (3) identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the elements with an associated state value at that time instance that is below its associated median value; and (4) determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. Id. Appellant argues that the claim language thus requires several very specific method steps, including measuring specific values, calculating specific values, identifying specific numbers of elements, and determining whether a network has departed from an equilibrium state based on this information. App. Br. 8. The claims, Appellant contends, therefore do not recite merely an abstract idea. Id. Appellant disputes the Examiner’s finding that “measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements” or “calculating for each element an associated median value that is a median of the state values associated with that element” can be construed as “gathering” data. App. Br. 9. According to Appellant, the claims do not use the term “gather,” 12 Appeal 2016-007620 Application 13/312,332 and the claims do not recite gathering any arbitrary data in any arbitrary manner. Id. The Examiner responds that the claims are directed to a judicially- created exception (i.e., an abstract idea) without adding significantly more. Ans. 13. Specifically, the Examiner finds independent claims 1,10, and 18 recite the step of identifying a first total number and a second total number by comparing the associated state value for each of the time instances to its calculated associated median value (i.e., a threshold) and determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance (i.e., using rules to determine a departure from an equilibrium state). Id. The Examiner finds this abstract idea is analogous to concepts that have been identified as abstract by the courts, such as the idea of comparing new and stored information and using rules to identify options or the idea of collecting and comparing known information. Id. The Examiner finds that the claimed steps of “measuring a state of each of the elements” and “calculating for each element an associated median value,” performed in order to collect state values for each element and establish an associated median value for each element, are considered to be directed to steps of mere data gathering in conjunction with the abstract idea, which add insignificant activity to the judicial exception and do not therefore add a meaningful limitation to the method of determining whether the network has departed from an equilibrium state. Id. at 13-14. Alternatively, the Examiner finds, the sole step of measuring the plurality of state values is directed to a step of data gathering of information and the recited steps of “calculating ... an associated median value that is a 13 Appeal 2016-007620 Application 13/312,332 median of the state values,” “identifying ... a first total number of the elements ... and a second total number of the elements”, and “determining whether the network has departed from an equilibrium state based on the first total number and the second total number” is directed to the abstract idea of manipulating the gathered information (i.e., the measured/determined plurality of state values) using mathematical relationships. Ans. 14. The Examiner finds these steps of calculating a median value, identifying “total number[s]” and determining an output based on the “total number[s]” are based on well-known mathematical formulae or relationships. Id. The Examiner cites Parker v. Flook, 437 U.S. 584, 594-95 (1978) and Diamond v. Diehr, 450 U.S. 175, 192 n. 14 (1981) as establishing that the idea of manipulating gathered information using mathematical formulae is essentially an abstract idea. Id. Finally, the Examiner concludes that the limitations reciting use of a computer are limited to setting forth generic computer components claimed to perform the basic functions of retrieving and processing or comparing data and amount to no more than instructions to implement the abstract idea on a computer. Ans. 15. We are not persuaded by Appellant’s arguments with respect to claims 1-9 and 18-20. Section 101 sets forth the categories of patentable subject matter, providing: “Whoever invents or discovers any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof, may obtain a patent therefor, subject to the conditions and requirements of this title.” The Federal Circuit, and the Supreme Court, have repeatedly held that claims reciting only abstract ideas, such as mental processes, are not directed to patentable subject matter. See, 14 Appeal 2016-007620 Application 13/312,332 e.g., Bilski v. Kappos, 130 S.Ct. 3218, 3225 (2010); Gottschalkv. Benson, 409 U.S. 63, 67 (1972). Claim 1 recites, in relevant part: measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements; calculating for each element an associated median value that is a median of the state values associated with that element; identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the elements with an associated state value at that time instance that is below its associated median value; and determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. In other words, claim 1 requires determining the median value for a set of measured values for each network element, and determining the number of measurements that fall above or below the determined medium as a measure of the system’s equilibrium. We agree with the Examiner that this limitation requires little more than a process of calculation, and one that could be calculated by an individual mentally, with no more than a pencil and paper. As such, we conclude that the limitation in question is directed to nonstatutory subject matter and is unpatentable under § 101. CyberSource Corp. v. Retail Decisions, Inc., 654 F.3d 1366, 1371-72 (Fed. Cir. 2011). 15 Appeal 2016-007620 Application 13/312,332 Nor do we find that the fact that claim 1 is directed to a “computer- implemented method for performing a functional assessment of a network” alters our conclusion. Appellant’s Specification describes the use of generic personal computers and commercially available software. See, e.g., Spec. ^ 87 (“Matlab R2010b, version 7.11.0.584 (64 bit) and the IMSL statistical library in FORTRAN (Compaq Visual Fortran Professional Edition, version 6.6B) were used for all computations using personal computers”) (emphasis added). Our reviewing court has been quite clear that the basic character of a process claim drawn to an abstract idea is not changed by claiming only its performance by ordinary computers. See CyberSource, 654 F.3d at 1375 (citing In reAbele, 684 F.2d 902, 908 (C.C.P.A. 1982). However, claim 10 recites “a network element state measurement unit to measure a state of each of the elements at a plurality of time instances.” As we have explained supra, we find that the claim term “network element state measurement unit to measure ...,” when read with respect to the corresponding disclosures of Appellant’s Specification, requires specific structural elements. We therefore conclude that claim 10, and its dependent claims, therefore recite an additional physical structural element in addition to the claimed purely mental steps recited in the rest of the claims, such that it requires a specific device (e.g., an MEA or MEG) for making the measurements. As such, we conclude that these claims are not directed solely to nonstatutory subject matter. We consequently affirm the Examiner’s rejection of claims 1-9 and 18-20 upon this ground and we reverse the rejection of claims 10-17. 16 Appeal 2016-007620 Application 13/312,332 C. Rejection of claims 1-20 under 35 U.S.C. $ 103(a) Issue Appellant argues the Examiner erred in finding that the combined cited prior art teaches or suggests using an associated median value that is a median of the state values. App. Br. 10. Analysis The Examiner finds John teaches all of the limitations of claim 1, with the exception that, although John discloses that an associated control mean value is calculated, wherein the control mean value is representative of a norm value, John fails to disclose using an associated median value that is a median of the state values. Final Act. 8. The Examiner also finds that John does not teach that a median value that is a median of the state values associated with that element serves as the median value. Id. The Examiner finds Hay discloses using a control group’s median of normal values as a set standard that is used to know how close unknown data is to a known “normal” condition. Final Act. 8 (citing Hay col. 16,11. 47- 53). The Examiner concludes that it would have been obvious to one of ordinary skill in the art to substitute the calculation of the associated mean value by John with the calculation of a median value representative of a normal/control condition, as taught by Hay. The Examiner finds that the substitution of one known statistical value representative of a normal/control set of values for another would yield predictable results to one of ordinary skill in the art. Final Act. 8. 17 Appeal 2016-007620 Application 13/312,332 Appellant argues that if, as the Examiner acknowledges, John does not teach or suggest a median of the state values, it logically follows that John also does not teach or suggest: [Identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the elements with an associated state value at that time instance that is below its associated median value, as recited by claim 1. App. Br. 10. Appellant asserts the Examiner also does not identify any teaching or suggestion of Hay or John ’190 that teaches or suggests this limitation. Id. Appellant asserts that the “median values” recited in claim 1 are not arbitrary median values but, rather, claim 1 recites “calculating for each element an associated median value that is a median of the state values associated with that element.” App. Br. 11. Therefore, argues Appellant, each element of the network has an associated median value, and that median value is a median of the state values for that particular element (i.e., the current element being analyzed). Id. In contrast, Appellant contends, the mean values identified by the Examiner in John are not based on current responses being analyzed but, rather, are previously determined values from a separate control group. Id. Similarly, asserts Appellant, the median values in Hay, which were cited by the Examiner, are also based on a separate control group. Id. Appellant acknowledges that the Examiner relies upon John ’ 190 as teaching this latter limitation as a “self-norm.” App. Br. 11 (citing Final Act. 9). Appellant, however, argues that John ’190 does not mention the term “median.” Id. Furthermore, Appellant argues, John ’190 teaches that the self-normalized data is compared with the next occurring time segment. 18 Appeal 2016-007620 Application 13/312,332 Id. (citing, e.g., John ’190 col. 3,11. 36^14). Appellant contends that John ’ 190 therefore teaches comparing current data to past historical data, as opposed to claim l’s requirement that the median value for each element is calculated based on the measured state values of the element. Id. Appellant therefore argues that the median values will vary based on the measured state values. Id. According to Appellant, the median values in the “identifying” step of claim 1 thus represent medians of the state values being addressed in the “identifying” step (not data from a previous control group or other past historical data). Id. Furthermore, Appellant argues, for any given time instance, other than the first and last time instance, the “identifying” step will use median values that are based on measured state values that occur before, during, and after that time instance. App. Br. 11-12. However, Appellant argues, John and Hay disclose the use of static data from a separate control group, and John ’190 uses past historical data. Id. at 12. Finally, argues Appellant, the Examiner allegedly impermissibly relies upon hindsight reasoning in an attempt to combine various unrelated teachings of the references in a manner that is not suggested by the prior art. App. Br. 12. According to Appellant, the recited median values in the “identifying” step represent medians of the state values being addressed in the “identifying” step, and not data from a previous control group or other past historical data. Id. Appellant argues that the cited references do not teach or suggest identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated median value, and a second total number of the 19 Appeal 2016-007620 Application 13/312,332 elements with an associated state value at that time instance that is below its associated median value. Id. at 12-13. The Examiner responds that John teaches using a “control mean value” of the state values and further teaches the step of: [Identifying for each of the time instances a first total number of the elements with an associated state value at that time instance that is above its associated control mean value, and a second total number of the elements with an associated state value at that time instance that is below its associated control mean value. Ans. 16 (quoting John col. 4,11. 12-26; col. 8,11. 10^19; col. 8-9,11. 61-6; Fig. 3 (depicting the identification for different series of tests (i.e. for each time instance))). The Examiner points out that, rather than using the “median” of the state values, John performs the above claimed limitation using the “control mean value,” which is representative of a norm value. Id. (citing John, col. 8,11. 31-50; cols. 7-8 11. 57-9). The Examiner cites Hay as teaching the use of a control group’s median of normal values as a norm value representative of a control condition. Ans. 16. The Examiner concludes that it would have been obvious to one of ordinary skill in the art to substitute the calculation of the associated mean value (i.e., one known statistical norm value) of John with the calculation of a median value representative of a control condition (i.e., another known statistical norm value), as taught by Hay, because the substitution of one known statistical value representative of a control set of values for another yields predictable results to one of ordinary skill in the art. Id. at 16-17. The Examiner points out that the above modification of John in view of Hay would result in the calculation of a median value in the calculating step of John and the use of the calculated control median value in the “identifying” step of John. Id. at 17. 20 Appeal 2016-007620 Application 13/312,332 However, the Examiner finds neither John nor Hay teaches or suggests a median value that is “a median of the state values associated with that element” serves as the “median value” used in the calculating and identifying steps. Ans. 17. The Examiner cites John ’190 as teaching a known alternative norm value (i.e., a “self-norm”) which is representative of a norm derived from samples gathered over time from a patient. Id. (citing John ’190 Abstr., cols. 10-11,11. 13-110). Specifically, the Examiner finds John ’190 teaches the use of the patient’s “self-norm” is a known alternative to the use of a “population norm” based on values obtained from a control population. Id. (citing John ’190 cols. 10-11,11. 13-11). The Examiner therefore concludes that it would have been obvious to one of ordinary skill in the art to have a median of the state values associated with that element serve as the median value (i.e., “a norm value”) of the combined references of John and Hay, because John ’190 discloses a known alternative norm (i.e., a “self-norm”) which is representative of a norm derived from samples gathered over time from the subject. Ans. 18. Furthermore, the Examiner concludes, it would also have been obvious to one of ordinary skill in the art to substitute the norm value (i.e., a control median value calculated based on “state values” from a control population) as disclosed by the combined references, with a norm value (i.e., a “self-norm”) calculated from the element’s own “state values,” as taught by John ’190, because the substitution of one known norm value for another yields predictable results to one of ordinary skill in the art. Id. We agree with the Examiner’s findings and conclusions and adopt them as our own, and thus decline to extensively repeat the Examiner’s 21 Appeal 2016-007620 Application 13/312,332 reasoning. Appellant argues that John does not teach determination of a median value in the analysis of its collected data, however, the Examiner relies upon Hay as teaching this limitation. Hay teaches: “As a corollary, a method of determining a plurality of standard statistical measurements such as the mean, median, standard deviation, confidence interval and other like statistical determinations of value parameters of the Wavefront images of groups of persons with similar and dissimilar disease states is disclosed.” Hay col. 1,11. 15-20. “[0]ne cannot show non-obviousness by attacking references individually where ... the rejections are based on combinations of references.” In re Keller, 642 F.2d 413, 426 (C.C.P.A. 1981). Similarly, Appellant argues that neither John nor Hay teaches analyzing data compared to previous measurements of a given element at a plurality of time instances, however, the Examiner relies upon John ’ 190 as teaching that data recorded (i.e., measurement taken) at a given site is: “compared on a statistical basis against the patient’s self-norm and population norms derived from groups of normal and abnormal groups of patients under specified conditions.” John ’190, Abstr. Specifically, John ’190 teaches: “A self-normed reference or ‘baseline’ set of brain wave data is comprised of a group of time segments for each derivation, for example, 24 segments, which are collected, analyzed, displayed and statistically compared, as a group, with the next occurring time segment of brain wave data....” John ’190 col. 3,11. 35^11. Nor are we persuaded that the Examiner impermissibly employed hindsight reasoning in arriving at the stated findings and conclusions. Our reviewing court has held that: 22 Appeal 2016-007620 Application 13/312,332 Any judgment on obviousness is in a sense necessarily a reconstruction based upon hindsight reasoning, but so long as it takes into account only knowledge which was within the level of ordinary skill at the time the claimed invention was made and does not include knowledge gleaned only from applicant’s disclosure, such a reconstruction is proper. In re McLaughlin, 443 F.2d 1392, 1395 (C.C.P.A. 1971). Appellant adduces no evidence of record, nor do we discern any, of any knowledge that could have been gleaned only from Appellant’s disclosure. Appellant argues claims 1,3, and 6 together, but relies upon essentially identical arguments for the remaining claims. See App. Br. 13- 21. We consequently affirm the Examiner’s rejection of claims 1-20 upon this ground. DECISION The Examiner’s rejection of claims 1-9 and 18-20 as unpatentable under 35 U.S.C. § 101 is affirmed. The Examiner’s rejection of claims 10-17 as unpatentable under 35 U.S.C. § 101 is reversed. The Examiner’s rejection of claims 1-20 as unpatentable under 35 U.S.C. § 103(a) is affirmed. No time period for taking any subsequent action in connection with this appeal may be extended under 37 C.F.R. § 1.136(a)(1). See 37 C.F.R. § 1.136(a)(l)(iv). AFFIRMED 23 Copy with citationCopy as parenthetical citation